The Pueblo City-County Health Department says two people have died and 41 others are in the hospital with the flu.
The department says both of the people who died were middle aged and had underlying medical conditions.
The health department is urging anyone with existing health problems to avoid crowds until this outbreak of the flu subsides.
El Paso County Public Health says 101 people have been hospitalized with flu in the Colorado Springs area. No deaths have been reported.