January 2003-2005 - Senate Minority Leader.
January 7, 2003 - Daschle announces that he will not be running for president in 2004 and will remain in the Senate.
November 2, 2004 - Loses his Senate seat to Republican John Thune by a vote of 49% to 51%.
March 5, 2005-2009 - Serves as special public policy adviser at the Washington branch of law firm Alston & Bird.
December 2, 2006 - Announces that he will not be running for president in 2008.
2007 - Co-founds the Bipartisan Policy Center with George Mitchell, Bob Dole, and Howard Baker.
December 11, 2008 - President-elect Barack Obama nominates Daschle to be secretary of health and human services and director of the White House Office of Health Reform.
January 8, 2009 - Confirmation hearings for Daschle begin in the Senate.
February 2, 2009 - In a letter to the Senate Finance Committee, Daschle admits to errors on his tax returns. The issue involves Daschle's use of a car and driver he didn't disclose on his income taxes, and nonpayment of taxes on more than $80,000 he earned in consulting fees after leaving the Senate. He paid $146,000 in back taxes and interest to correct the errors.
February 3, 2009 - Announces that he is withdrawing his name from consideration as secretary of health and human services.
November 18, 2009-present - Senior policy adviser for business law firm DLA Piper.