Other medications and herbal supplements also may increase your risk of bleeding. Medications that can interact with aspirin include:

  • Heparin
  • Ibuprofen (Advil, Motrin, others), when taken regularly
  • Corticosteroids
  • Some antidepressants (clomipramine, paroxetine, others)

Taking some dietary supplements can also increase your bleeding risk. These include:

  • Danshen
  • Dong quai
  • Evening primrose oil
  • Ginkgo
  • Omega-3 fatty acids (fish oil)
  • Policosanol
  • Willow bark

If you take daily aspirin, is it still safe to take an aspirin during a heart attack?

If you think you're having a heart attack, the most important thing for you to do is call 911 or emergency medical services. Don't delay calling for help. Aspirin alone won't save your life if you're having a heart attack.

The operator may advise you to chew an aspirin, but will first ask questions to make sure you're not allergic to aspirin or have any other health conditions that would make taking an aspirin during a heart attack too risky. It's OK to chew an aspirin if your doctor has previously told you to do so if you think you're having a heart attack — but call 911 or emergency medical services first.

Should you take a coated aspirin?

Enteric-coated aspirin is designed to pass through your stomach and not disintegrate until it reaches your small intestine. It's gentler on the stomach and may be appropriate for some people who take a daily aspirin, especially in those with a history of gastritis or ulcers. However, some researchers think there's no evidence that taking an enteric-coated aspirin decreases your chance of developing gastrointestinal bleeding. Talk to your doctor if you're concerned about ways to decrease your bleeding risk.

Source: http://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797